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What are design requirements for stainless steel bioreactors?

Data: 2021-04-14


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What are design requirements for stainless steel bioreactors?
As we all know, stainless steel microbial reactors belong to a sterile working environment, and the biological strains are independent and directional. An excellent stainless steel bioreactor should prevent the derivation of bacteria and phages from the production of the tank to the production process. In order to ensure the smooth and efficient microbial fermentation process.

Let Paragon learn about the requirements for the stainless steel 316L bioreactor in production and design.

  • Excellent mass transfer/heat transfer effect:

Excellent material mixing performance, so as to provide the best growth temperature of the culture. In the process of animal cell culture, in addition to mixing well, animal cells must not be broken to ensure the smooth progress of the biological fermentation culture process.

  • Requirements for materials:

The materials often used are 316L, 304L, 304, 916; the inner surface of the fermenter should be smooth, without dead corners, to prevent material accumulation, and easy to clean and sterilize after the fermentation; and the culture medium (including the feed material), the fermentation broth ( The materials in contact with microorganisms, bacteria, vaccines, cells, etc. must be made of materials that are non-toxic, corrosion-resistant, do not absorb the above-mentioned substances, and do not chemically react with the above-mentioned substances. 

316L laboratory Stainless Steel  bioreactor

The 316L stainless steel bioreactor developed by the Paragon laboratory bioreactor supplier comes with an excellent automated sterilization program and is equipped with a steam generator for sterilization.

  • Requirements for internal and external environment:

In the cultivation process, the active substances involved must meet the biosafety standards. It is necessary to prevent the contamination of all external microorganisms, but also to prevent the cultivation substances in the bioreactor from polluting the surrounding environment. 

Therefore, the biological fermentation tank should be a system device with good sealing performance, and its emptying and discharging gas and liquid in the tank need to be filtered to remove active substances;

  • The stainless steel bioreactor body must have a SIP process:

Since the entire biological culture needs to be carried out under aseptic conditions, aseptic needs to ensure the three basic elements of aseptic process, aseptic raw materials and aseptic products. The production of bioreactors should meet a series of production standards.

The 316L stainless steel laboratory bioreactor developed by the Paragon laboratory bioreactor supplier comes with an excellent automated sterilization program, equipped with a steam generator for sterilization, and is used in the microbiology laboratory of scientific research institutions to ensure the effective conduct of microbial fermentation experiments.